Vitamin K deficiency (eg, malnutrition, malabsorption, or hemorrhagic disease of the newborn) with coagulopathy. Vitamin K1 is notindicated for empiric treatment of anticoagulant ingestion, as mostcases do not require treatment, and its use will delay the onset of anelevated prothrombin time as a marker of a toxic ingestion. Drug Indications ::Įxcessive anticoagulation caused by coumarin and indanedione derivatives, as evidenced by elevated prothrombin time. Fresh frozen plasma or whole blood is indicated forimmediate control of serious hemorrhage. The response to vitamin K1is variable, and the optimal dosage regimen is unknown it isinfluenced by the potency and amount of the ingested anticoagulant,vitamin K pharmacokinetics, and the patient’s hepatic biosyntheticcapability. After parenteral vitamin K1administration, there is a 6- to 8-hour delay before vitaminK–dependent coagulation factors begin to achieve significant levels,and peak effects are not seen until 1–2 days after the initiation oftherapy. Note: Vitamin K3 (menadione) is not effective in reversing excessive anticoagulation caused by these agents. In adequate doses, vitamin K1 reverses the inhibitory effects of coumarin and indanedione derivatives on the synthesis of these factors.
Vitamin K1 is an essential cofactor in the hepatic synthesis of coagulation factors II, VII, IX, and X.
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